Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection |
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Authors: | O'Connor Shelby L Becker Ericka A Weinfurter Jason T Chin Emily N Budde Melisa L Gostick Emma Correll Michael Gleicher Michael Hughes Austin L Price David A Friedrich Thomas C O'Connor David H |
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Affiliation: | Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA. doconnor@primate.wisc.edu |
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Abstract: | CD8+ T cell responses rapidly select viral variants during acute human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection. We used pyrosequencing to examine variation within three SIV-derived epitopes (Gag386-394GW9, Nef103-111RM9, and Rev59-68SP10) targeted by immunodominant CD8+ T cell responses in acutely infected Mauritian cynomolgus macaques. In animals recognizing all three epitopes, variation within Rev59-68SP10 was associated with delayed accumulation of variants in Gag386-394GW9 but had no effect on variation within Nef103-111RM9. This demonstrates that the entire T cell repertoire, rather than a single T cell population, influences the timing of immune escape, thereby providing the first example of conditional CD8+ T cell escape in HIV/SIV infection. |
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