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A new Hind III restriction fragment length polymorphism in the hemophilia A locus |
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| Authors: | P. Ahrens T. A. Kruse M. Schwartz P. B. Rasmussen N. Din |
| Affiliation: | (1) Institute of Human Genetics, Aarhus University, The Bartholin Building, DK-8000 Aarhus C, Denmark;(2) Section of Clinical Genetics, Department of Paediatrics, Rigshospitalet, DK-2100 Copenhagen, Denmark;(3) Department of Biotechnology, Nordisk Gentofte, DK-2820 Gentofte, Denmark |
| Abstract: | Summary Using a fragment of the cDNA for human coagulation factor VIII as a hybridization probe, we have detected a new polymorphic Hind III site in intron 19 of the factor VIII gene. The frequency of the minor allele is 0.30. This polymorphism shows strong linkage disequilibrium with a previously described BclI polymorphism in intron 18. |
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