Allosteric interactions and QSAR: on the role of ligand hydrophobicity |
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| Authors: | Hansch Corwin Garg Rajni Kurup Alka Mekapati Suresh Babu |
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| Institution: | Department of Chemistry, Pomona College, 645North College Avenue, Claremont, CA 91711, USA. atessier@pomona.edu |
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| Abstract: | A study of a very large database of QSAR (9100) has uncovered a few unusual examples where as one increases the hydrophobicity of the members of a set of congeners, activity decreases until at a certain point, activity begins to increase. Obviously a change in mechanism is involved. The only way we have found to rationalize this unusual event is by a change in the structure of the receptor. We have found this to occur with hemoglobin, a substance first used to define allosteric reactions. |
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