Solid-phase synthesis of oligomeric deoxynucleic-thiourea (DNT) and deoxynucleic S-methylthiourea (DNmt): a neutral/polycationic analogue of DNA |
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| Authors: | Arya D P Bruice T C |
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| Institution: | Department of Chemistry, University of California, Santa Barbara 93106, USA. |
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| Abstract: | A solid-phase synthesis for oligomeric DNmt is reported. Synthesis proceeds in 3'-5' direction and involves coupling of a protected 3'-isothiocyanate with the corresponding 5'-amine of the growing oligo chain. The difference in oligomeric thiourea/S-methylthiourea binding to DNA is investigated. |
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