Free amino acid changes in the cerebral cortex of experimental uremic rat |
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Authors: | Susumu Kikuchi Hiroyuki Matsumoto Masaharu Ito |
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Affiliation: | 1. Department of Internal Medicine, Otaru National Sanatorium, Japan 2. The First Department of Internal Medicine, Sapporo Medical College, Japan
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Abstract: | The levels of free amino acids in the cerebral cortex of acute and chronic uremic rats were examined. Amino acids significantly elevated were aspartate, glutamine, glycine, histidine, ornithine, phenylalanine, phosphoethanolamine and taurine, whereas 1-methyl histidine and 3-methyl histidine were specifically detected in uremic rats. Glutamate, arginine and carnosine disclosed a significant reduction. There was no change in the concentrations of γ-aminobutyrate and alanine. The above findings were essentially identical in both acute and chronic uremia. It was conjectured that these changes of amino acid levels in the brain might participate in the progress of uremic encephalopathy. |
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