The role of mucins in host-parasite interactions. Part I-protozoan parasites |
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Authors: | Hicks S J Theodoropoulos G Carrington S D Corfield A P |
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Institution: | Centre for Biomedical Sciences, School of Applied Sciences, University of Wales Institute Cardiff, Cardiff, UK. shicks@uwic.ac.uk |
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Abstract: | Parasite-derived mucin-like molecules might be involved in parasite attachment to and invasion of host cells. In addition, parasites might secrete mucin-degrading enzymes, enabling the penetration of protective mucus gels that overlie the mucosal surfaces of their potential hosts. Furthermore, they might generate binding ligands on the membrane-bound mucins of host cells by using specific glycosidases. It is possible that host mucins and mucin-like molecules prevent the establishment of parasites or facilitate parasite expulsion. They might also serve as a source of metabolic energy and adhesion ligands for those parasites adapted to exploit them. Sally Hicks and colleagues here review the biochemical properties of mucins and mucin-like molecules in relation to interactions (established and putative) between protozoan parasites and their hosts. |
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