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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
Authors:Christian Baumgartner  Stefanie Toifl  Matthias Farlik  Florian Halbritter  Ruth Scheicher  Irmgard Fischer  Veronika Sexl  Christoph Bock  Manuela Baccarini
Institution:1. Department of Microbiology, Immunobiology and Genetics, Center for Molecular Biology of the University of Vienna, Max F. Perutz Laboratories, Vienna Biocenter (VBC), 1030 Vienna, Austria;2. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria;3. Department for Biomedical Sciences, Institute of Pharmacology and Toxicology, University of Veterinary Medicine, 1210 Vienna, Austria;4. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria;5. Saarland Informatics Campus, Max Planck Institute for Informatics, Saarbrücken, Germany
Abstract:
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  • Keywords:hematopoietic stem cells  emergency hematopoiesis  hematopoietic stem cell activation  hematopoietic stem cell exhaustion  oxidative stress  mitochondrial fitness  intracellular signaling  ERK pathway  AKT/mTORC1 pathway  feedback regulation of signaling
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