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Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium
Authors:Anna M Nicholson  Cora Olpe  Alice Hoyle  Ann-Sofie Thorsen  Teja Rus  Mathilde Colombé  Roxanne Brunton-Sim  Richard Kemp  Kate Marks  Phil Quirke  Shalini Malhotra  Rogier ten Hoopen  Ashraf Ibrahim  Cecilia Lindskog  Meagan B Myers  Barbara Parsons  Simon Tavaré  Mark Wilkinson  Douglas J Winton
Institution:1. Cancer Research-UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK;2. Wellcome Trust-Medical Research Council, Cambridge Stem Cell Institute, Cambridge, UK;3. Norwich Research Park BioRepository, James Watson Road, Norwich NR4 7UQ, UK;4. Pathology and Tumour Biology, Level 4, Wellcome Trust Brenner Building, St. James University Hospital, Beckett Street, Leeds LS9 7TF, UK;5. Department of Histopathology, Box 235, CUHFT, Cambridge, UK;6. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala 751 85, Sweden;7. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-120, 3900 NCTR Road, Jefferson, AR 72079, USA;8. MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Abstract:
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  • Keywords:human  colon  epithelium  crypt  stem cells  dynamics  mutation  clone  fission  expansion
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