Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans |
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| Authors: | Choudhary Muhammad Iqbal Khan Naik T Musharraf Syed G Anjum Shazia Atta-Ur-Rahman |
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| Institution: | HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. hej@cyber.net.pk |
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| Abstract: | Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6beta-hydroxyadrenosterone (4), 9alpha-hydroxy-11-ketotestosterone (5), and 6beta-hydroxy-11-ketotestosterone (6). Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis. |
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| Keywords: | Adrenosterone Microbial transformation Cunninghamella elegans Hydroxylation |
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