| 综述与专论: 纳米酶的抗菌机理与应用 |
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| 引用本文： | 唐燕,仇智月,许卓斌,高利增.综述与专论: 纳米酶的抗菌机理与应用[J].生物化学与生物物理进展,2018,45(2):118-128. |
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| 作者姓名： | 唐燕 仇智月 许卓斌 高利增 |
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| 作者单位： | 扬州大学医学院转化医学研究院，江苏省非编码RNA基础与临床转化重点实验室，扬州 225001,扬州大学医学院转化医学研究院，江苏省非编码RNA基础与临床转化重点实验室，扬州 225001,扬州大学医学院转化医学研究院，江苏省非编码RNA基础与临床转化重点实验室，扬州 225001,扬州大学医学院转化医学研究院，江苏省非编码RNA基础与临床转化重点实验室，扬州 225001 |
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| 基金项目： | 国家自然科学基金面上项目(81671810)和江苏省科技项目基础研究计划(自然科学基金)面上项目(BK20161333) |
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| 摘 要： | 细菌耐药性和抗生素滥用是一个世界性难题，需要开发新型抗菌剂，既能够高效杀菌，又能避免耐药性问题并具有较好的生物和环境相容性．纳米酶具有调控ROS自由基的能力，可以高效杀死多种革兰氏阳性和阴性致病菌以及顽固性生物膜；同时纳米酶具有较好的稳定性、生物相容性、可回收再利用等优点，在促进伤口愈合、龋齿防治和环境防污方面具有重要的应用前景．
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| 关 键 词： | 纳米酶，ROS，细菌，耐药性，生物膜 |
| 收稿时间： | 2017/12/15 0:00:00 |
| 修稿时间： | 2017/12/15 0:00:00 |
Reviews and Monographs: Antibacterial Mechanism and Applications of Nanozymes |
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| TANG Yan,QIU Zhi-Yue,XU Zhuo-Bin and GAO Li-Zeng.Reviews and Monographs: Antibacterial Mechanism and Applications of Nanozymes[J].Progress In Biochemistry and Biophysics,2018,45(2):118-128. |
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| Authors: | TANG Yan QIU Zhi-Yue XU Zhuo-Bin and GAO Li-Zeng |
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| Institution: | Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225001, China,Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225001, China,Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225001, China and Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225001, China |
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| Abstract: | Antibiotic-resistance of bacteria and antibiotics abuse is a global challenge. It is urgent to develop novel bactericide alternative to kill bacteria efficiently but without causing new resistance and biosafety issue. Nanozymes are nanomaterials with intrinsic enzyme-like activities which regulate reactive oxygen species (ROS) by redox reactions. This property can be used to suppress many gram-positive and gram-negative virulent bacteria and biofilms. Meanwhile, nanozymes have high stability, biocompatibility and reusability compared to other biocidal agents. Therefore nanozymes present a promising antibacterial alternative in the application of wound healing, caries prevention and marine antifouling. |
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| Keywords: | nanozymes ROS bacteria antibiotic resistance biofilm |
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