| 综述与专论: 纳米酶及其细胞活性氧调控 |
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| 引用本文： | 董海姣,张弛,范瑶瑶,张薇,顾宁,张宇.综述与专论: 纳米酶及其细胞活性氧调控[J].生物化学与生物物理进展,2018,45(2):105-117. |
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| 作者姓名： | 董海姣 张弛 范瑶瑶 张薇 顾宁 张宇 |
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| 作者单位： | 东南大学生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京 210096,东南大学生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京 210096,东南大学生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京 210096,东南大学生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京 210096,东南大学生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京 210096,东南大学生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京 210096 |
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| 基金项目： | 国家重点研发计划项目资助(2017YFA0205502) |
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| 摘 要： | 随着纳米技术的不断进步，人们逐渐开发出能够模拟天然抗氧化酶催化活性的无机纳米材料．这些纳米材料能够模拟过氧化物酶、过氧化氢酶、超氧化物歧化酶等天然酶的催化过程，从而调控细胞的氧化还原水平．本文从金属化合物、贵金属以及碳基纳米酶的角度，阐述了它们对细胞内活性氧(ROS)的调控作用以及在各种氧化应激相关疾病治疗中的应用．作为一种新型的模拟酶，纳米酶有望在生物医学领域中为疾病治疗提供一种新的策略．
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| 关 键 词： | 纳米酶，活性氧，细胞，氧化还原，肿瘤治疗 |
| 收稿时间： | 2017/12/15 0:00:00 |
| 修稿时间： | 2018/1/16 0:00:00 |
Reviews and Monographs: Nanozyme and Their ROS Regulation Effect in Cells |
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| DONG Hai-Jiao,ZHANG Chi,FAN Yao-Yao,ZHANG Wei,GU Ning and ZHANG Yu.Reviews and Monographs: Nanozyme and Their ROS Regulation Effect in Cells[J].Progress In Biochemistry and Biophysics,2018,45(2):105-117. |
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| Authors: | DONG Hai-Jiao ZHANG Chi FAN Yao-Yao ZHANG Wei GU Ning and ZHANG Yu |
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| Institution: | School of Biological Science & Medical Engineering, Southeast University, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China,School of Biological Science & Medical Engineering, Southeast University, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China,School of Biological Science & Medical Engineering, Southeast University, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China,School of Biological Science & Medical Engineering, Southeast University, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China,School of Biological Science & Medical Engineering, Southeast University, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China and School of Biological Science & Medical Engineering, Southeast University, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China |
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| Abstract: | With the development of nanotechnology, researchers have successfully constructed some inorganic nanomaterials, which can mimic the catalytic activity of natural antioxidant enzymes. These nanomaterials can regulate the redox levels of cells by mimicking the catalytic processes of natural enzymes such as peroxidase, catalase, and superoxide dismutase. This paper describes the intracellular ROS regulation and oxidative stress-related diseases treatment effects of metal compounds nanozymes, noble metal nanozymes and carbon-based nanozymes from the perspective of their enzyme-like activities. As a new type of enzyme mimic, nanozymes are expected to provide a new strategy for the treatment of diseases in the future biomedical field. |
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| Keywords: | nanozyme reactive oxygen cell redox tumour therapy |
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