Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells |
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| Authors: | Hong Seong Su Lee Seon A Kim Nahyun Hwang Ji Sang Han Xiang Hua Lee Mi Kyeong Jung Jae Kyung Hong Jin Tae Kim Youngsoo Lee Dongho Hwang Bang Yeon |
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| Affiliation: | a College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea
b School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea |
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| Abstract: | A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 μM, respectively. |
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| Keywords: | Isodon excisus Lamiaceae Pyrrolidinone diterpenoid Nitric oxide inhibitor |
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