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Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold |
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| Authors: | Zhao Yunxue Liu Min Chagnault Vincent Wang Juying Zhang Xiumei Murphy Paul V |
| Institution: | a Department of Pharmacology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China b Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland c School of Chemistry, National University of Ireland, Galway, University Road, Galway, Ireland |
| Abstract: | Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand. |
| Keywords: | Peptidomimetic Somatostatin Angiogenesis Cell cycle Apoptosis Migration Stress fiber |
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