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Structure based evolution of a novel series of positive modulators of the AMPA receptor |
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| Authors: | Jamieson Craig Maclean John K F Brown Christopher I Campbell Robert A Gillen Kevin J Gillespie Jonathan Kazemier Bert Kiczun Michael Lamont Yvonne Lyons Amanda J Moir Elizabeth M Morrow John A Pantling John Rankovic Zoran Smith Lynn |
| Affiliation: | a Merck Research Laboratories, MSD, Newhouse, Motherwell, Lanarkshire ML1 5SH, UK b Merck Research Laboratories, MSD, PO Box 20, Oss, 5340 BH, Netherlands |
| Abstract: | Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19. |
| Keywords: | AMPA receptor Allosteric modulator SBDD Indane Scaffold hopping |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |