Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina

Authors:	Xu Min Andrews Kathy T Birrell Geoff W Tran Truc Linh Camp David Davis Rohan A Quinn Ronald J

Affiliation:	^a Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia ^b Queensland Institute for Medical Research, Brisbane, QLD 4006, Australia ^c Griffith Medical Research College, a joint program of Griffith University and Queensland Institute for Medical Research, Australia ^d Australian Army Malaria Institute, Brisbane, QLD 4051, Australia

Abstract:	Mass-directed isolation of the CH₂Cl₂/CH₃OH extract from a marine sponge of the genus Pseudoceratina resulted in the purification of a new antimalarial bromotyrosine alkaloid, psammaplysin H (1), along with the previously isolated analogs psammaplysins G (2) and F (3). The structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis. All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC₅₀ 0.41 μM) and selective (>97-fold) antimalarial activity.

Keywords:	Bromotyrosine alkaloid Antimalarial Alkaloid Marine sponge
本文献已被 ScienceDirect PubMed 等数据库收录！