Natural products from <Emphasis Type="Italic">Peperomia</Emphasis>: occurrence,biogenesis and bioactivity |
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| Authors: | Yasmin Valero Gutierrez Lydia F Yamaguchi Marcilio M de Moraes Christopher S Jeffrey Massuo J Kato |
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| Institution: | 1.Research Support Center in Molecular Diversity of Natural Products, Institute of Chemistry,University of S?o Paulo,S?o Paulo,Brazil;2.Department of Chemistry,University of Nevada,Reno,USA |
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| Abstract: | The Peperomia is one of the giant genus among Angiosperms with approximately 1600 species spread in the tropics. Their species are valuable as ornamental and several medicinal uses were described but their phytochemistry is poorly investigated compared to Piper (2000 species). In spite of this scarcity, typical classes of secondary metabolites isolated from their species are characterized as polyketides, meroterpenes, chromenes, phenylpropanoids, lignans and amides, among which 2-acylcyclohexane-1,3-diones, orsellinic acid-based meroterpenes and secolignans (peperomins) are very specific to Peperomia. The bioactivities of several compounds indicated their potential as antiparasites, antimicrobial, antiviral, cytotoxic agents against several tumoral strains and also as herbicides. |
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