Influence of initial large dose on subsequent uptake of therapeutic radioiodine in thyroid cancer patients |
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| Affiliation: | 1. Health and Safety Laboratory, Reactor Research Centre, Kalpakkam, Tamil Nadu 603 102, India;2. Radiation Medicine Centre, Tata Memorial Centre Annexe, Parel, Bombay 400 012, India;1. Department of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza str. 63, 80-308, Gdansk, Poland;2. Department of Solid State Physics, Faculty of Applied Physics and Mathematics, Gdansk University of Technology, G. Narutowicza str. 11/12, 80-233, Gdansk, Poland;3. Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44-52, 01-224, Warsaw, Poland;1. Institute for Energy Research, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China;2. School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China;1. Instituto Federal de Educação, Ciência e Tecnologia do Piauí – IFPI, 64760-000, Campus São João do Piauí-PI, Brazil;2. Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA;3. Departamento de Física, Universidade Federal do Piauí – UFPI, 64049-550, Teresina, PI, Brazil;4. Laboratório de Materiais Funcionais Avançados (LaMFA), Departamento de Física, Universidade Federal do Ceará - UFC, 60440-554, Fortaleza, CE, Brazil;5. Department of Physics and Center for 2-Dimensional and Layered Materials, The Pennsylvania State University, 16802, University Park, PA, USA;6. Faculdade de Ciências Exatas e Naturais, Universidade Federal do Pará, Campus Universitário de Tocantins, Cametá, PA, 68.400-000, Brazil;7. Departamento de Física, Universidade Federal do Paraná - UFPR, 80060-000, Curitiba, PR, Brazil;8. Pós Graduação em Ciências dos Materiais, Centro de Tecnologia, 64049-550, Teresina, PI, Brazil;1. LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy;2. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy;3. Dementia Research Group, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK;4. Servicio Neurologia, Hospital Universitario Reina Sofía Córdoba, Spain;5. Department of Gerontological, Geriatric and Psychiatric Sciences, Università Cattolica del Sacro Cuore, Rome, Italy;6. Victoria Centre, Swindon, UK;7. Service de Neurologie et Neuropsychologie, CHU Timone and INSERM U1106, Aix-Marseille Univ, Marseille, France;8. Bordeaux CMRR, France;9. Laboratory of Neurosciences, Inst of Molecular Medicine, Lisbon, Portugal;10. Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;11. Department of Geriatric Psychiatry, Zentralinstitut für Seelische, Gesundheit Mannheim, University of Heidelberg, Mannheim, Germany;12. Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany;13. University of Eastern Finland, Univ Hospital, Kuopio, Finland;14. Memory Disorders Research Unit, Rigshospitalet, Copenhagen, Denmark;15. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn, Bonn, Germany;p. Department of Psychiatry, University of Bonn, Bonn, Germany;q. German Center for Neurodegenerative Disease (DZNE), Bonn, Germany;r. RICE - The Research Institute for the Care of Older People, Royal United Hospital, Bath, UK;s. Technische Universität Psychiatrische Klinik, Munchen, Germany;t. Mercer''s Institue for Research on Ageing, St James'' Hospital, Dublin, Ireland;u. Memory Unit, Neurology Service, Hospital Santa Creu i, Sant Pau, Barcelona, Spain;v. Fundacion CITA-Alzheimer Fundazioa, San Sebastian, Spain;w. Section of Gerontology and Geriatrics, University of Perugia, Perugia, Italy;x. Department of Neurology, Univ Hospital Alexandrovska, Sofia, Bulgaria;y. Memory Clinic, University Center for Medicine of Aging Basel, Felix Platter Hospital, Basel, Switzerland;z. Clinical Neurology, Dept of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy;11. Department of Geriatric Medicine, Radboud University Medical Centre, Radboud Alzheimer Centre, Nijmegen, Netherlands;22. CHU de Lille, Université de Lille 2, Lille, France;33. Department of Psychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany;44. Université de Liège, Cyclotron Research Centre, Liege, Belgium;55. Servicio de Geriatría, Hospital Universitario Ramón y Cajal, Madrid, Spain;66. Neurology Department, Coimbra University Hospital, Coimbra, Portugal;77. Neurologie de la Mémoire et du Langage, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France;88. 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece;99. Alzheimer Centre, Vrije Univ Medical Centre, Amsterdam, Netherlands;1010. Alzheimer centre Maastricht University, Maastricht, Netherlands;1111. Clinical Memory Research Unit, Lund University, Memory Clinic Malmö, Sweden;1212. University of Oxford, Nuffield Dept of Medicine, John Radcliffe Hospital, Oxford, UK;1313. Memory Assessment and Research Centre MARC, Moorgreen Hospital, Southampton, UK;1414. Department of Psychiatry Research, Zurich, Switzerland;1515. Dokuz Eylül University, Izmir, Turkey;pp. Department of Internal Medicine and Geriatrics, University Hospitals and University of Geneva, Geneva, Switzerland;qq. Memory Clinic and Laboratoire de Neuroimagerie du Vieillissement (LANVIE), University Hospitals and University of Geneva, Geneva, Switzerland |
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| Abstract: | Fifty-two patients with differentiated thyroid cancer, following thyroidectomy were studied by administering a quantity of up to 5 mCi of [131I]sodium iodide. In most of these patients, radioiodine uptake values obtained with the subsequent therapeutic dose were markedly lower than those observed with the initial doses. This observation was verified in seven of the patients with differentiated thyroid cancer, by measuring the radioiodine uptake with a second dose of 4.5 mCi of [131I]sodium iodide. Calculations showed that the major etiology was probably therapeutic irradiation of the thyroid by the first dose. |
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