Astatine (211At) as a therapeutic radionuclide. The plasma: Blood cell distribution in vitro |
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| Institution: | 1. Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;1. IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy;2. Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20072 Pieve Emanuele, Milan, Italy;3. King’s College London, Centre for Inflammation Biology and Cancer Immunology, Peter Gorer Department of Immunobiology, Great Maze Pond, SE1 1UL London, UK;4. Francis Crick Institute, NW1 1AT London, UK;5. Max-Planck-Institute for Biophysical Chemistry, Am Faßberg 11, 37077 Göttingen, Germany;6. Pronto Soccorso Veterinario Laudense, Via Milano 22, 26900 Lodi, Italy;7. University of Bologna, Department of Veterinary Medical Science, via Tolara di Sopra, 40064 Ozzano dell’Emilia, Bologna, Italy;8. San Michele Veterinary Hospital, via I maggio 26838 Tavazzano con Villavesco, Lodi, Italy;1. Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;2. Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital, SUS Malmö, SE-205 02, Malmö, Sweden;3. Barsebäck Kraft AB, Box 524, SE-246 25, Löddeköpinge, Sweden |
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| Abstract: | Therapy of carcinoma of the thyroid may include the use of the radionuclide 131I, which localizes to thyroid tissue. In considering the use of another halogen, the α particle emitting radionuclide astatine, 211At, there is also the requirement that it too can be taken up by the thyroid. However, in view of its short half-life (7.2 h) it is important that its transport in the blood is not a factor likely to render it less available. For example, retention of 211At by red cells may retard its uptake by the thyroid. This in vitro in-vestigation of the partitioning of the 211At between erythrocytes and plasma indicates that it is not strongly bound by the red cells in blood. |
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