Say when: reversible control of gene expression in the mouse by lac |
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| Authors: | Scrable Heidi |
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| Affiliation: | Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA. hs2n@virginia.edu |
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| Abstract: | In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator-repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse. |
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