Alteration of steroid hormone sulfation andd-glucaric acid excretion in lead workers |
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Authors: | A. Ferioli P. Apostoli L. Romeo |
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Affiliation: | 1. Institute of Occupational Health, University of Brescia, p.le Spedali Civili 1, 25125, Brescia, Italy 2. Institute of Occupational Health, University of Verona, Verona, Italy
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Abstract: | The capability of lead to interfere with the first and/or second phase of enzymatic reaction of biotransformation has been investigated in ten lead workers and in ten controls by studying the steroid hormone sulfation andd-glucaric acid (GA) urinary excretion. No statistical differences have been found for the total amount of urinary steroids, whereas a decrease of about 50% was observed for the sulfated fraction in lead workers. The mean value for the GA excretion in the exposed subjects (1.8±0.7 mmol/mol creatinine) was significantly lower than in the control group (4.4±0.8 mmol/mol creatinine). In spite of the small number of investigated subjects, it can be hypothesized that an interaction of lead with sulfotransferase exists. The decreased GA excretion does not prove an altered activity of microsomal enzymes, although inhibition of microsomal activity following lead exposure was previously reported. |
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Keywords: | KeywordHeading" >Index Entries Lead exposure 1st and 2nd phase of biotransformation steroid sulfation font-variant:small-caps" >d-glucaric acid excretion |
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