Pregnancy Loss Following Coxsackievirus B3 Infection in Mice during Early
Gestation Due toHigh Expression of Coxsackievirus-Adenovirus Receptor (CAR) in Uterus and
Embryo |
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| Authors: | Ji Young Hwang Kyung Min Lee Yun Hwa Kim Hye Min Shim Young Kyung Bae Jung Hye Hwang Hosun Park |
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| Institution: | 1)Department of Microbiology, College of Medicine, Yeungnam University, 170 Hyeonchung-ro, Namgu, Daegu 705-717, Republic of Korea;2)Department of Pathology, College of Medicine, Yeungnam University, 170 Hyeonchung-ro, Namgu, Daegu 705-717, Republic of Korea;3)Department of Obstetrics and Gynecology, College of Medicine, Hanyang University Hospital, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of Korea |
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| Abstract: | Coxsackieviruses are important pathogens in children and the outcomes of neonatal
infection can be serious or fatal. However, the outcomes of coxsackievirus infection
during early gestation are not well defined. In this study, we examined the possibility of
vertical transmission of coxsackievirus B3 (CVB3) and the effects of CVB3 infection on
early pregnancy of ICR mice. We found that the coxsackievirus and adenovirus receptor
(CAR) was highly expressed not only in embryos but also in the uterus of ICR mice. CVB3
replicated in the uterus 1 to 7 days post-infection (dpi), with the highest titer at 3
dpi. The pregnancy loss rate in mice infected with CVB3 during early gestation was 38.3%,
compared to 4.7% and 2.7% in mock-infected and UV-inactivated-CVB3 infected pregnant mice,
respectively. These data suggest that the uterus and embryo, which express abundant CAR,
are important targets of CVB3 and that the vertical transmission of CVB3 during early
gestation induces pregnancy loss. |
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| Keywords: | CAR coxsackievirus early gestation pregnancy loss |
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