Activation of Cre Recombinase Alone Can Induce Complete Tumor Regression |
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| Authors: | Yulin Li Peter S Choi Stephanie C Casey Dean W Felsher |
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| Institution: | Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.; Sanford Burnham Medical Research Institute, United States of America, |
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| Abstract: | The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p53−/− mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors. |
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