| 大花红天素分离、合成及其含量分析 |
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| 引用本文： | 黄宏卿,程科军,梁高林,胡昌奇.大花红天素分离、合成及其含量分析[J].天然产物研究与开发,2005,17(4):468-470. |
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| 作者姓名： | 黄宏卿 程科军 梁高林 胡昌奇 |
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| 作者单位： | 复旦大学药学院天然药物化学教研室,上海,200032 |
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| 摘 要： | 研究大花红天素的分离、合成，并对大花红天素的含量进行分析测定。通过东京化成HP-20和硅胶柱色谱进行分离；以2-甲基-3-丁烯-2-醇和溴代四乙酰葡萄糖通过SN2反应合成大花红天素，合成收率为18％；通过HPLC-ELSD对大花红天素的含量进行分析，通过对8种样品的分析，测定大花红景天和红景天饮片中分别含大花红天素2．06％、0.83％，其他样品中未检出大花红天素。作者对大花红天素进行了首次合成并建立了相应的分析测定方法。
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| 关 键 词： | 大花红天素 大花红景天 HPLC-ELSD 红景天 |
| 收稿时间： | 2005-01-28 |
| 修稿时间： | 2005-03-28 |
Separation, Synthesis and Content Analysis of Crenulatin |
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| HUANG Hong-qing,CHENG Ke-jun,LIANG Gao-lin,HU Chang-Qi.Separation, Synthesis and Content Analysis of Crenulatin[J].Natural Product Research and Development,2005,17(4):468-470. |
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| Authors: | HUANG Hong-qing CHENG Ke-jun LIANG Gao-lin HU Chang-Qi |
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| Abstract: | To seporate and synthesize crenulatin and analyze its content in eight collected samples, crenulatin was separated by HP-20 and silica gel column chromatography, synthsized by 2-methyl-3-buten-2-ol and aectobrome-glucose and analyzed by HPLC-ELSD method. After analyzing eight samples, we found erenulatin existed only in the roots of Rhodiola crenulata and Rhodialo decoction pieces and accounted for 2.06% and 0.86% ,respectively. Crenulatin was synthesized for the first time and its correspondent analytical method was established. |
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| Keywords: | crenulatin Rhodiola crenulata HPLC-ELSD Rhodiola |
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