The human herpesvirus 6 U21–U24 gene cluster is dispensable for virus growth |
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Authors: | Chyntia Jasirwan Huamin Tang Akiko Kawabata Yasuko Mori |
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Affiliation: | Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Hyogo, Kobe, Japan |
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Abstract: | Human herpesvirus 6 (HHV‐6) is a T‐lymphotrophic virus belongs to the genus Roseolovirus within the beta herpesvirus subfamily. The U20–U24 gene cluster is unique to Roseoloviruses; however, both their function and whether they are essential for virus growth is unknown. Recently, bacterial artificial chromosome (BAC) techniques have been used to investigate HHV‐6A. This study describes generation of a virus genome lacking U21–U24 (HHV‐6ABACΔU21–24) and shows that infectious virus particles can be reconstituted from this BAC DNA. Our data indicate that the HHV‐6 U21–U24 gene cluster is dispensable for virus propagation. |
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Keywords: | bacterial artificial chromosome human herpesvirus‐6 U21 U24 |
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