In vitro experimental studies of sialyl Lewis x and sialyl Lewis a on endothelial and carcinoma cells: crucial glycans on selectin ligands |
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Authors: | Risto Renkonen Pirkko Mattila Marja-Leena Majuri Jarkko Rabina Sanna Toppila Jutta Renkonen Laura Hirvas Jaana Niittymaki Juha Pekka Turunen Ossi Renkonen Timo Paavonen |
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Institution: | (1) Department of Bacteriology and Immunology Helsinki, Finland;(2) Department ofInstitute of Biotechnology, University of Helsinki, Helsinki, Finland;(3) Department of Pathology, Haartman Institute, Helsinki, Finland |
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Abstract: | Extravasation from the blood of malignant tumour cells that form metastasis and leukocytes that go into tissues require contact
between selectins and their sialyl Lewis x and sialyl Lewis a (sLex and sLea respectively) decorated ligands. Endothelial
cells have been shown to express sLex epitopes in lymph nodes and at sites of inflammation, and this is crucial for the selectin-dependent
leukocyte traffic. Besides the ability to synthesize sLex on sialylated N-acetyllactosamine via the action of α(1,3)fucosyltransferase(s),
endothelial cells can also degrade sLex to Lewis x through the action of α(2,3)sialidase(s). In addition, several epithelial
tumors possess the machinery to synthesize sLex, which facilitates their adhesion to endothelial E- and P-selectin.
This revised version was published online in November 2006 with corrections to the Cover Date. |
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Keywords: | metastasis leukocytes sialyl Lewis x sialyl Lewis a endothelial carcinoma glycans selectin |
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