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Opposing orientations of the anti‐psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin |
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| Authors: | Michael D Feldkamp Lokesh Gakhar Nisha Pandey Madeline A Shea |
| Institution: | 1. Department of Biochemistry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa;2. Protein Crystallography Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa |
| Abstract: | |
| Keywords: | molecular recognition drug specificity promiscuous binding TFP trifluoromethyl CF3 thermodynamics energetics alternate conformers pharmaceuticals QSAR |