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Monoclonal antibody-directed immunopurification and identification of cytochromes P-450 |
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| Authors: | F K Friedman R C Robinson S S Park H V Gelboin |
| Affiliation: | 1. Medical Nobel Institute, Department of Biochemistry I, Karolinska Institutet, S-104 01 Stockholm, Sweden;2. Department of Biophysics, Arrhenius Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden |
| Abstract: | A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle. The primary structure of this atrial peptide is H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly- (sequence in text) Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-(Arg)-Tyr-OH. The biological activity of this peptide is identical to that of atrial natriuretic factor and cardionatrin I isolated from rat atria. |
| Keywords: | Please send correspondence to: Dr. T.G. Flynn Department of Biochemistry Queen's University Kingston Ontario Canada K7L 3N6 |
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