A new recurring chromosome 13 abnormality in two older patients with de novo acute myeloid leukemia: An Indian experience |
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| Authors: | Trivedi P J Patel P S Brahmbhatt M M Patel B P Gajjar S B Dalal E N Shukla S N Shah P M Bakshi S R |
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| Institution: | Department of Cell Biology Division, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad - 380 016, India. |
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| Abstract: | We report here two cases of trisomy 13 in acute myeloid leukemia M1 subtype. short-term unstimulated bone marrow and peripheral blood lymphocyte culture showed 47, XY, +13 in all metaphase plates and trisomy 13 was confirmed with whole chromosome paint probes. Trisomy 13 in AML-M1 is a rare numerical abnormality. This is the first Indian report of sole trisomy 13 in AML-M1. Here, we present two cases of elder male patients, which may constitute a distinct subtype. |
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| Keywords: | Acute myeloid leukemia-M1 recurrent sole abnormality trisomy 13 |
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