Antimutagenic activity of 8-hydroxyisoflavones and 6-hydroxydaidzein from soybean miso |
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Authors: | Chen Yu-chi Inaba Miyuki Abe Naoki Hirota Akira |
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Institution: | Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. |
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Abstract: | The antimutagenic activity of four isoflavones isolated from soybean miso toward three kinds of mutagens, AF-2, MNNG, and Trp-P-1, was evaluated by the Ames test. 8-Hydroxyisoflavones had greater suppressive potency than that of daidzein, and 6-hydroxydaidzein had almost the same activity as daidzein. These results indicated the number of hydroxy and methoxy groups and the position of these functional groups were important for antimutagenic activity. |
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