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Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide. |
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| Authors: | R C Kennedy G R Dreesman J T Sparrow A R Culwell Y Sanchez I Ionescu-Matiu F B Hollinger J L Melnick |
| Abstract: | A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide. |
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