Penicillin-binding proteins of pathogenic Escherichia coli strains |
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| Authors: | RCC Ferreira SOP Costa LCS Ferreira LR Trabulsi |
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| Institution: | Laboratório de Genética de Microrganismos, Departamento de Microbiologia, Universidade de São Paulo, ICB II, Av. Prof. Lineu Prestes, 1374, 1°andar, Cidade Universitária, São Paulo, SP 05508-900, Brazil;Laboratório de Fisiologia Celular, Instituto de Biof??sica Carlos Chagas Filho, CCS-UFRJ, Cidade Universitária, Rio de Janeiro, RJ 21949-900, Brazil;Laboratório Especial de Microbiologia, Instituto Butantan, São Paulo, SP, Brazil |
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| Abstract: | The penicillin-binding proteins of 11 pathogenic Escherichia coli strains, including enteropathogenic, enterotoxigenic, enteroinvasive, enteroaggregative, and enterohemorrhagic E. coli, were detected in gels following the labeling of isolated cell envelopes with 3H]benzylpenicillin. The electrophoretic profiles, sensitivities to and morphological changes induced by β-lactam antibiotics showed that the penicillin-binding proteins of most pathogenic E. coli possess structural and physiological functions similar to those of E. coli K12. |
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| Keywords: | Penicillin-binding protein Pathogenic Escherichia coli β-Lactam antibiotic Enteropathogenic Escherichia coli |
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