Oncolytic Properties of a Mumps Virus Vaccine Strain in Human Melanoma Cell Lines |
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| Authors: | Y. I. Ammour O. O. Ryabaya A. V. Milovanova A. V. Sidorov I. E. Shohin V. V. Zverev T. V. Nasedkina |
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| Affiliation: | 1.Mechnikov Institute of Vaccines and Sera,Moscow,Russia;2.Blokhin Russian Cancer Research Center,Ministry of Health of the Russian Federation,Moscow,Russia;3.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia;4.OOO Center of Pharmaceutical Analytics,Moscow,Russia |
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| Abstract: | The oncolytic potential of the attenuated mumps virus (MV) vaccine strain Leningrad-3 (L-3) was evaluated in a panel of four human metastatic melanoma cell lines. The lines were shown to be susceptible and permissive to MV infection. Efficient MV replication led to death of melanoma cells, but the effect differed among the cell lines. Possible mechanisms mediating the selectivity of MV L-3 towards the cell lines were explored. Replicative and oncolytic activity of MV was found to depend on the expression pattern of type I interferon genes. None of the melanoma cell lines showed induction of expression of the total spectrum of genes required to inhibit virus replication. Based on the results, MV L-3 was assumed to be a promising oncolytic agent for human melanoma cells. |
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