Study on the aerosol transmission of Hantaan virus |
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Authors: | Che Fengxiang Lu Jianchun Meng Lingyin Li Jingsong Li Junbao Tong Yongyi Zhang Chaolong Zhang Songle Hu Qingxuan Lui Mingxia |
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Institution: | (1) Institute of Microbiology and Epidemiology, 20 # Eastern Street, Fengtai District, 100071 Beijing, Peoples’ Republic of China |
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Abstract: | We studied some important aspects constituting aerosol transmission of Hantaan virus, including the possibility of viral aerosol
generated by rodents, airborne stability, rodent’s susceptibility to aerosol challenge, and field air sampling for the virus.
Our results showed that Hantaan virus aerosol could be generated through the activities of infected mice, and cause specific
infection among the exposed animals. Several kinds of rodents such asApodemus agrarius, weaning mice and suckling mice were found to be rather sensitive to the aerosol challenge of Hantaan virus. The 50% of inhaled
lethal dose (LD50) of suckling mice is 0.73 (1.4–0.37) plaque-forming unit (pfu). Hantaan virus aerosol was relatively stable in the air at
18–20°C and 70–90% relative humidity. The biological decay rate of the viral aerosol was 4.1% per min during 90 min. We also
successfully sampled and isolated Hantaan virus from the working field atmosphere. The data obtained in the study provided
more solid evidence for Hantaan virus aerosol transmission among rodents and from rodents to human-beings. |
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Keywords: | Hantaan virus Airborne transmission Aerosol Inhalation Survival Field sampling |
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