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注意缺陷多动障碍儿童肠道菌群特点及与行为问题的相关性研究
引用本文:李希, 陈向坚, 陈竞建, 等. 注意缺陷多动障碍儿童肠道菌群特点及与行为问题的相关性研究[J]. 中国微生态学杂志, 2024, 36(3): 313-316. doi: 10.13381/j.cnki.cjm.202403010
作者姓名:李希  陈向坚  陈竞建  卓晓峰
作者单位:宁德师范学院附属宁德市医院儿科,福建 宁德 352100
摘    要:目的

分析注意缺陷多动障碍(ADHD)儿童肠道菌群特点与行为问题的相关性。

方法

选取2022年1月到2023年5月我院收治的96例ADHD患儿和健康体检的96例儿童,分别作为研究组和对照组。对所有儿童粪便样本进行宏基因组测序并分析肠道菌群特点。采用Conners儿童行为问卷-家长版(PSQ)评估两组儿童的行为。采用Pearson相关性分析肠道菌群分布与行为问题的相关性。

结果

研究组患儿肠道菌群α−多样性低于对照组,肠杆菌属、气味杆菌属和枸橼酸杆菌属相对丰度均高于对照组,韦荣球菌属、拟杆菌属、双歧杆菌属和普氏栖粪杆菌相对丰度均低于对照组,差异均具有统计学意义(P<0.05)。研究组患儿Conners PSQ问卷评分高于对照组(P<0.05)。研究组患儿Conners PSQ问卷各因子评分与肠道肠杆菌属、气味杆菌属和枸橼酸杆菌属均呈正相关(P<0.05),与韦荣球菌属、拟杆菌属、双歧杆菌属和普氏栖粪杆菌均呈负相关(P<0.05)。

结论

ADHD儿童肠道菌群构成与健康儿童不同,不同肠道菌群与患儿行为问题有相关性。



关 键 词:注意缺陷多动障碍   肠道菌群   行为障碍
收稿时间:2023-10-27
修稿时间:2023-12-29

Characteristics of intestinal flora and their correlation with behavioral problems in children with attention deficit hyperactivity disorder
LI Xi, CHEN Xiangjian, CHEN Jingjian, et al. Characteristics of intestinal flora and their correlation with behavioral problems in children with attention deficit hyperactivity disorder[J]. Chinese Journal of Microecology, 2024, 36(3): 313-316. doi: 10.13381/j.cnki.cjm.202403010
Authors:LI Xi  CHEN Xiangjian  CHEN Jingjian  ZHUO Xiaofeng
Affiliation:Department of Pediatrics, Ningde Hospital Affiliated to Ningde Normal University, Ningde, Fujian 352100, China
Abstract:ObjectiveTo analyze the correlation between characteristics of intestinal flora and behavioral problems in children with attention deficit hyperactivity disorder (ADHD). MethodsA total of 96 children with ADHD and 96 healthy children in the hospital between January 2022 and May 2023 were enrolled in the observation group and control group respectively. The metagenomic sequencing of stool samples was performed to analyze the characteristics of intestinal flora. The behavioral problems of children were evaluated by using Conners Parent Symptom Questionnaire (PSQ). The correlation between distribution of intestinal flora and behavioral problems was analyzed. ResultsThe α-diversity of intestinal flora in observation group was higher than that in control group; the relative abundances of Enterobacter, Flavobacteriaceae and Citrobacter in observation group were higher, while those of Veillonella, Bacteroides, Bifidobacterium and Faecalibacterium prausnitzii were lower than those in control group respectively, and the difference was statistically significant (P<0.05). The scores of Conners PSQ in observation group were higher than those in control group (P<0.05). Enterobacter, Flavobacteriaceae and Citrobacter were positively correlated with Conners PSQ scores (P<0.05), while Veillonella, Bacteroides, Bifidobacterium and Faecalibacterium prausnitzii were negatively correlated with them (P<0.05). ConclusionThe intestinal flora in ADHD children are different from those in healthy children. Different intestinal flora are correlated with behavioral problems.
Keywords:Attention deficit hyperactivity disorder  Intestinal flora  Behavioral disorder
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