Development of a versatile computer integrated control system for bioprocess controls |
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Authors: | Deyu Kong Reiner Gentz Junli Zhang |
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Institution: | (1) Human Genome Sciences Inc., 9410 Key West Ave., Rockville, MD, 20850, U.S.A |
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Abstract: | A general approach is described for the implementation of a networked multi-unit computer integrated control system. The use
of data acquisition hardware and graphical programming tools alleviates tedious programming and maintains potency and flexibility.
One application of the control system, the control of a mammalian cell perfusion culture based on a key nutrient glucose concentration,
was demonstrated. The control system offers customized user interface for all process control parameters and allows the flexibility
for continued improvement and implementation of new tailored functions. The temperature, pH, dissolved oxygen and glucose
level were accurately controlled.
This revised version was published online in June 2006 with corrections to the Cover Date. |
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Keywords: | bioreactor computer control data acquisition glucose control |
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