幽门螺杆菌感染与慢性口臭关系的初步研究

目的 调查主诉口臭患者的幽门螺杆菌（H．pylori）感染率和主诉消化不良的口臭发生率。方法 研究对象为125例主诉慢性口臭患者和212例主诉慢性消化不良患者。口臭以口气挥发性硫化物（VSC）检测与闻诊联合诊断，H．pylori感染以^14C-尿素呼气试验诊断。结果 125例主诉慢性口臭的患者有87例是真性口臭，其余38例为假性口臭，真性口臭患者的H．pylori感染率显著高于假性口臭（40．2％和13．2％，P〈0．01）。212例主诉慢性消化不良的患者发生口臭105例（49．5％）、感染H．pylori 94例（44．3％），H．pylori阳性患者的口臭发生率显著高于H．pylori阴性患者（57．5％和43．2％，P〈0．05）。无论何种主诉，大部分口臭患者属于VSC阳性（88．5％），但H．pylori阳性患者和H．pylor阴性患者口气VSC水平差异无显著性，VSC阳性口臭和VSC阴性口臭的H．pylori感染率差异也无显著性。结论 H．pylori感染可能与口臭的发生有一定关系，但口气VSC并非由H．pylori直接产生。

A pilot study on the relationship between H.pylori infection and chronic halitosis

Objective Data on the role of Helicobacter pylori(H.pylori) in the develoPment of halitosis was controversial.The aim of this study was to investigate the prevalence of H.pylori infection in patients with chief complaint of halitosis and the prevalence of halitosis in patients with chief complaint of dyspepsia.Methods The study patients consisted of 125 patients with chief complaint of halitosis and 212 patients with chief complaint of dyspepsia.All patients were examined for the real halitosis and the status of H.pylori.Halitosis was confirmed by the measurement of oral volatile sulphur compounds(VSC) and organoleptic measurment,and H.pylori infection was detected by ~(14)C-urea breath test.Results Of 125 patients with chief complaint of halitosis,87 patients were confirmed to suffer with real halitosis and the 38 patients were of pseudohalitosis.The prevalence of H.pylori infection in the real halitosis patients was significantly higher than that in the pseudohalitisis patients(40.2% VS.13.2%,P<0.05).Of 212 patients with chief complaint of dyspepsia,105 patients(49.5%) were confirmed to suffer with real halitosis,and 94 patients(44.3%) were H.pylori-positive.The prevalence of real halitosis in patients with H.pylori infection was significantly higher than that in patients without H.pylori infection(57.5% VS.43.2%,P<0.05).Most of real halitosis was oral VSC-positive,both in patients with chief complaint of halitosis(77/87,88.5%) and in those of dyspepsia(93/105,88.5%).However,there was no statistic difference between H.pyori-positive patients and H.pylori negative in oral VSC concentration,and there was no statistic difference between VSC-positive halitosis patients and VSC-negative halitosis patients in the prevalence of H.pylori infection.Conclusion H.pylori infection might play a causative role in the development of halitosis,but the oral VSC may be not produced directly by the organism.