GB virus type C/hepatitis G virus: a non-pathogenic flavivirus associated with prolonged survival in HIV-infected individuals |
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Authors: | Polgreen Philip M Xiang Jinhua Chang Qing Stapleton Jack T |
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Affiliation: | Department of Internal Medicine, Iowa City VA Medical Center, Internal Medicine SW34-P, GH, University of Iowa, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USA. |
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Abstract: | GB virus C (GBV-C) is a common virus that does not appear to cause disease. GBV-C persists in up to 50% of exposed individuals, and virus replication appears to be in lymphocytes including CD4+ T cells. GBV-C infection is common among HIV-positive people, and several studies have found that HIV-positive individuals co-infected with GBV-C survive for statistically significantly longer periods of time than people without GBV-C. In vitro studies suggest that GBV-C inhibits HIV replication and alters cytokine, chemokine and chemokine receptor expression. Thus, GBV-C may be a major factor influencing the natural history of HIV disease. |
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