ESTDAB: a collection of immunologically characterised melanoma cell lines and searchable databank |
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Authors: | Graham Pawelec Steven G Marsh |
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Institution: | 1. University of Tübingen Center for Medical Research, ZMF, Waldh?rnlestr. 22, 72072, Tubingen, Germany 2. Anthony Nolan Research Institute, Royal Free Hospital, London, UK
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Abstract: | Cancer immunologists working in humans often require panels of tumour cell lines expressing different combinations of HLA
alleles and other characteristics. Sources of cell lines are usually large cell banks carrying little immunologically relevant
information on the available cells and limited numbers of different lines from the same type of tumour. Access to cells with
desired combinations of characteristics is, therefore, difficult. Here, we describe an interactive database of a large collection
of melanoma cell lines which have been extensively characterised for HLA genotype and surface expression, oncogene and tumour
antigen expression, cytokine secretion, surface molecule expression, adhesion to extracellular matrix components, cytokine
gene polymorphisms and other factors of interest to immunologists. This enables investigators to search for cells with particular
constellations of HLA alleles, tumour antigens, etc., and then request these from the cell bank. This European Searchable
Tumour Cell Line and Data Bank (ESTDAB) was established as a Research Infrastructure of the European Commission. For access
to the databank and further details, please go to . |
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Keywords: | |
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