Swimming training promotes cardiac remodeling and alters the expression of mRNA and protein levels involved in calcium handling in hypertensive rats |
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Authors: | Jamille Locatelli,Leonardo Viní cius Monteiro de Assis,Carolina Morais Araú jo,André ia Carvalho Alzamora,Wanderson Geraldo de Lima,Maria José Campagnole-Santos,Robson Augusto dos Santos,Mauro Cé sar Isoldi |
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Affiliation: | 1. Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil;2. Sports Center, Federal University of Ouro Preto, Ouro Preto, Brazil;3. Departament of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil;4. Department of Biological Science, Institute of Exact and Biological Sciences, Ouro Preto, Brazil;5. National Institute of Science and Technology in Nano-Biopharmaceutical Innovation, Belo Horizonte, Brazil;6. Departament of Physiology and Biophysics, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil |
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Abstract: | AimThe aim of this study was to identify the effects of swimming training on the mRNA expression and protein levels of the calcium handling proteins in the hearts of renovascular hypertensive rats submitted to swimming protocol during 6 weeks.Main methodsFischer rats with renovascular hypertension 2-kidney 1-clip (2K1C) and SHAM groups were divided among sedentary and exercised groups. The exercise protocol lasted for 6 weeks (1 h/day, 5×/week), and the mean arterial pressure, cardiomyocytes hypertrophy parameters, mRNA expression and protein levels of some calcium handling proteins in the left ventricle were evaluated.Key findingsSwimming training was able to reduce the levels of mean arterial pressure in the hypertensive group compared to 2K1C SED, and to promote cardiac hypertrophy in SHAM EX and 2K1C EX groups in comparison to the respective control groups. The mRNA levels of B-type natriuretic peptide were reduced in the 2K1C EX when compared to 2K1C SED. The mRNA and protein levels of the sarcoplasmic reticulum Ca2 +-ATPase increased after the swimming training in SHAM and 2K1C groups. The mRNA and protein levels of phospholamban, displayed an increase in their levels in the exercised SHAM and in hypertensive rats in comparison to their respective controls; while mRNA levels of Na+/Ca2 + exchanger was reduced in the left ventricle comparing to the sedentary hypertensive rats.SignificanceTaken altogether, we provide evidence that the aerobic training may lead to cardiac remodeling, and modulate the calcium handling proteins expression in the heart of hypertensive rats. |
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Keywords: | Calcium handling Renovascular hypertension Swimming Cardiac hypertrophy |
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