Differential behavior between S100A9 and adiponectin in coronary artery disease. Plasma or epicardial fat |
| |
Authors: | Rosa María Agra Elvis Teijeira-Fernández Domingo Pascual-Figal Sánchez-Más Jesús Ángel Fernández-Trasancos Juan Sierra José Ramón González-Juanatey Sonia Eiras |
| |
Institution: | 1. Department of Cardiology and Coronary Unit, University Hospital of Santiago de Compostela, Spain;2. Department of Cardiology, University Clinical Hospital of Virgen de la Arrixaca, Spain;3. Department of Internal Medicine, University of Virgen de la Arrixaca, Spain;4. Health Research Institute, University Hospital of Santiago de Compostela, Spain;5. Department of Heart Surgery, University Hospital of Santiago de Compostela, Spain |
| |
Abstract: | AimsS100A9 is a new inflammatory marker associated with obesity and cardiovascular disease. Because epicardial adipose tissue (EAT) is an inflammatory source in coronary artery disease (CAD), our aim was to evaluate the S100A9 levels in plasma and EAT and its association with CAD.Main methodsBlood, EAT and/or subcutaneous adipose tissue (SAT) biopsies were obtained from 89 patients undergoing elective cardiac surgery. Plasma S100A9 and adiponectin were analyzed by enzyme-linked immunosorbent assay (ELISA) and mRNA expression in both fat pads and were measured by real-time polymerase chain reaction (PCR).Key findingsOur results have shown higher levels of plasma S100A9 in patients with CAD than those without (29 10–50] vs. 17 3–28] ng/mL; p = 0.007). They were dependent on the number of injured-coronaries (p = 0.002) with tendency toward negative association with plasma adiponectin (p = 0.139). Although EAT expressed higher levels than SAT and their levels were higher in CAD patients, this last difference did not reach statistical significance. However, there was a positive correlation between neutrophils and EAT S100A9 expression (p = 0.007) that may reveal an increase of neutrophil filtration on this fat pad.SignificancePlasma S100A9 levels are increased in chronic CAD. The absence of differences regarding EAT S100A9 expression levels indicates a differential inflammatory process between fat tissues and blood in CAD process. |
| |
Keywords: | S100A9 Epicardial adipose tissue Coronary artery disease |
本文献已被 ScienceDirect 等数据库收录! |
|