Physiological evaluation of a rabbit kidney perfused with VS41A |
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Authors: | Arnaud Françoise G Khirabadi Bijan Fahy Gregory M |
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Affiliation: | Naval Medical Research Center, Combat Casualty Care, Resuscitative Medicine Program 503 R. Grant Ave, Silver Spring, MD 20910-7500, USA. |
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Abstract: | The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated. |
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Keywords: | Cryopreservation Machine-perfused kidney Dimethyl sulfoxide Formamide Propylene glycol Isolated perfused kidney VS55 |
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