Neutralization epitope in the envelope glycoprotein of simian retrovirus-1 (SRV-1) and identification of the virus receptor. |
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Authors: | J V Torres L L Werner A Malley E Benjamin |
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Affiliation: | Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616. |
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Abstract: | We previously demonstrated that the area encompassing residues 147-162 of the envelope protein of simian retrovirus serotype-1 (SRV-1) is the target for rhesus anti-SRV-1 neutralizing antibodies. A peptide representing amino acids 142-167 of envelope protein (gp70) is capable of inducing virus-neutralizing antibodies in mice. The virus receptor was immunoprecipitated from Raji cells using gp70 as the ligand. Antibodies to peptide 142-167 inhibit the immunoprecipitation, indicating that the receptor recognizes residues 142-167 of the viral envelope protein. |
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Keywords: | Type D immunodeficiency gp70 immunosuppression antibodies peptides |
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