Abnormalities of human chromosome 13 and in vitro radiosensitivity A study of 19 fibroblast strains |
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| Authors: | John Nove Warren W Nichols Ralph R Weichselbaum John B Little |
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| Institution: | 1. Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA 02115, USA;2. Department of Cytogenetics, Institute for Medical Research, Camden, NJ 08103, USA;3. Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115, U.S.A. |
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| Abstract: | The in vitro X-ray sensitivity of 19 fibroblast strains derived from patients bearing a deletion, trisomy, inversion, or translocation of all or part of chromosome 13 were determined with a clonogenic survival assay. The results were compared with data from similar experiments involving strains from normal controls and from individuals trisomic for 3 other autosomes. The results suggest the involvement of this chromosome with hypersensitivity to the cytotoxic effects of X-irradiation. Experiments involving the partial monosomies and trisomies seem to implicate a locus on 13q14. |
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