RBE of densely ionizing radiation for wild-type and radiosensitive mutants of yeast |
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Authors: | VG Petin NM Kabakova |
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Institution: | Research Institute of Medical Radiobiology, 249020 Obninsk U.S.S.R. |
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Abstract: | Survival curves were obtained for haploid and diploid yeasts, Saccharmyces cerevisiae, of wild-type strains and radiosensitive mutants exposed to γ-rays and α-particles. A correlation between the values of the relative biological effectiveness (RBE) of high-LET radiation and cell-repair capacity was found. The difference in radiosensitivities of the wild-type diploid strain and homozygous rad mutants incapable of recovery was significantly higher after low-LET radiation than after high-LET radiation. Possible reasons for the observed radiation responses to low- and high-LET exposure of yeast cells with various genotype are discussed. |
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