Functional evidence for abnormal maturation within a B-cell subpopulation of NZB mice |
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Authors: | Pamela B Nakajima Brigitte T Huber |
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Institution: | Cancer Research Center, Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111 USA |
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Abstract: | NZB mice develop a systemic autoimmune disease and have a subpopulation of B lymphocytes that spontaneously produce excessive amounts of IgM. These abnormal B cells reside within a specific B-cell subset that is affected by the CBA/N defect. In normal mice, this B-cell subset acquires in vitro responsiveness to certain thymus-independent antigens (TI-2) relatively late in ontogeny. We compared the functional development of neonatal B cells from NZB mice to that of normal mice of the same H-2 type. The acquisition of in vitro responsiveness to the TI-1 antigen, TNP-LPS and the TI-2 antigens, TNP-Dextran, TNP-Ficoll, and FITC-Ficoll was examined. TNP-LPS could elicit a response from both normal and NZB neonates. In contrast, responses to the TI-2 antigens were elicited early in life (<1 week) only from or at a higher level from NZB neonates. However, an accelerated appearance of B-cell differentiation antigens was not detected in NZB neonates compared to normal strains. We conclude, therefore, that a maturation or triggering defect occurs in a small B-cell subpopulation of NZB mice very early in life. |
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Keywords: | To whom correspondence should be addressed |
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