The differential effects of PGE on the immune response in normal and immunosuppressed mice |
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| Authors: | Cartesio Favalli Peter Leport Bernard M. Jaffe M.Gabriella Santoro Thomas Simmet Vera Del Gobbo Enrico Garaci |
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| Affiliation: | 1. Department of Surgery, S.U.N.Y. Downstate Medical Center, Brooklyn, New York U.S.A.;2. The Institute of Microbiology, University of Rome, Rome, Italy |
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| Abstract: | The effect of 16,16-dimethyl-PGE2-methyl ester (di-M-PGE2) on humoral and cellular immunoresponsiveness has been compared in normal mice and in mice immunosuppressed by splenectomy and thymectomy plus antithymocyte serum (ATS). Splenectomy resulted in immunosuppression manifested by augmentation of B-16 melanoma growth; this stimulatory effect was reversed by di-M-PGE2. In animals immunosuppressed by thymectomy plus ATS, di-M-PGE2 augmented the humoral and cellular immune responses; this was manifested by slowing of the growth of B-16 melanoma and by stimulating the number of plaque-forming cells, hemagglutinin titers, and delayed-hypersensitivity reactions to sheep erythrocytes. In contrast, in normal (nonthymectomized) mice, di-M-PGE2 was mildly immunosuppressive. Finally, adriamycin-immunosuppressed normal mice and this suppression were reversed by the addition of di-M-PGE2 to the treatment regimen. |
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| Keywords: | To whom all correspondence should be addressed: Department of Surgery S.U.N.Y. Downstate Medical Center 450 Clarkson Avenue Box 40 Brooklyn N.Y. 11203. |
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