Induction of the differentiation of memory T killer cells with factors released from macrophage-like cell lines |
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Authors: | Tsuyoshi Igarashi Yasuko Ikeda Hiroshi Saito Saeko Takano Tadamitsu Kishimoto Takao Shida |
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Institution: | 1. Clinical Research Center for Rheumato-Allergology, National Sagamihara Hospital, Sakuradai, Sagamihara, Kanagawa 228, Japan;2. The IIIrd Department of Internal Medicine, Osaka University Medical School, Fukushima, Osaka 553, Japan |
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Abstract: | Macrophage-like cell lines J774.1 and WEHI-3 as well as peritoneal exudate macrophages have been demonstrated to produce factors which induce the differentiation of memory cells into specific T killer cells in the absence of an added antigen. LPS stimulation was required for J774.1 cells and peritoneal macrophages to produce the factors but not for WEHI-3 cells. Interferon seemed to be one of the responsible factors. However, macrophages seem to produce other active factors; one has a molecular weight (MW) of more than 80,000 and lacks thymocyte mitogenic activity; another, with a weak thymocyte mitogenic activity, has a MW of 38,000 to 44,000. The low MW thymocyte mitogenic factor (interleukin-1) showed weak T killer cell differentiating activity. |
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Keywords: | To whom all correspondence should be addressed Current address: The IIIrd Department of Internal Medicine Osaka University Medical School Fukushima Osaka 553 Japan |
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