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Prostaglandin regulation of macrophage function: Effect of endogenous and exogenous prostaglandins |
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| Authors: | Mary Ellen Snider Richard H Fertel Bruce S Zwilling |
| Institution: | 1. Department of Microbiology, College of Biological Science, The Ohio State University, Columbus, Ohio 43210 U.S.A.;2. Department of Pharmacology, College of Medicine, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 U.S.A. |
| Abstract: | The expression of macrophage antitumor activity and the production of prostaglandins (PG) by operationally defined macrophage populations differed under varying culture conditions. Culture conditions that caused increased PGE2 production by activated macrophages resulted in an inhibition of their tumoricidal activity. In contrast, production of high levels of PGE2 by resident and elicited macrophages was associated with an increase in antitumor activity. The activation of resident or elicited cells by lipopolysaccharide (LPS) could be blocked by indomethacin. Treatment of these macrophages with PGE2 alone also resulted in their activation and subsequent tumor cell destruction. Activation of resident and elicited macrophages by LPS appears to be mediated by PGE2. |
| Keywords: | To whom all correspondence should be addressed at the Department of Microbiology |
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