Suppression of human lymphocyte DNA and protein synthesis in vitro by adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase inhibitors, 2′-deoxycoformycin (DCF) and erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) |
| |
Authors: | Howard Ratech Lloyd Kuritsky GJeanette Thorbecke Rochelle Hirschhorn |
| |
Institution: | 1. Department of Pathology, New York University School of Medicine, New York, New York 10016 USA;2. Department of Medicine, New York University School of Medicine, New York, New York 10016 USA |
| |
Abstract: | Adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase (ADA) inhibitors, 2′-deoxycoformycin or erythro-9-(2-hydroxy-3-nonyl) adenine, were investigated with regard to their effects on phytohemagglutinin-stimulated human lymphocytes in vitro. Protein and DNA synthesis were inhibited depending upon the specific nucleoside, presence or absence of ADA inhibitor, and time of addition of nucleoside to cultures. A possible role for the modified adenine nucleosides in causing in vivo immunodeficiency is proposed. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|