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Tumor cell differentiation modulates susceptibility to natural killer cells |
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| Authors: | Jerome Werkmeister Stephen L. Helfand Tina Haliotis Peter Rubin Hugh Pross John Roder |
| Affiliation: | 1. Department of Microbiology and Immunology, Queen''s University, Kingston, Ontario, K7L 3N6 Canada;2. Department of Radiation Oncology, Queen''s University, Kingston, Ontario, K7L 3N6 Canada;3. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02138 U.S.A. |
| Abstract: | Induced differentiation in three human cell lines altered their sensitivity specifically to human natural killer (NK) cells by affecting their expression of NK target antigens. Differentiation of HL-60, a promyelocytic leukemia cell line, and the erythroleukemic cell line K562 was accompanied by a concomitant decrease in susceptibility to NK-mediated lysis whereas induction of MeWo melanoma cells resulted in an enhanced sensitivity to lysis. Our findings suggest that target cell susceptibility to NK-mediated lysis may in part be dependent on the stage of differentiation of the tumor cell target. |
| Keywords: | To whom correspondence should be addressed: The Fred Hutchinson Cancer Research Center Division of Oncology 1124 Columbia Street Seattle Wash. 98104. |
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